NASA said in a budget phone call with reporters late Monday (March 28) that the three-year gap between Artemis 3 and Artemis 5 is will allow the agency to assess performance of HLS, which will include SpaceX and another company after a new selection process announced last week. Related: NASA gearing up for Artemis 1 'wet dress rehearsal' It appears NASA wants to use a 2027 launch to help build out its Gateway moon space station, but it has no listed launches in 2026 for either the moon or Gateway. Then crewed landings are planned for 2029, 20 with Artemis 6, 7 and 8. NASA's inspector general has said the first landing will be more likely in 2026, but even if the timeline goes to plan, the new budget documents show a three-year distance between moon landings.Ī published "moon to Mars planning manifest" shows the next human landing will be Artemis 5 in 2028, three years after Artemis 3. Following that, if NASA's plans go forward, are an Artemis 2 round-the-moon crewed mission in 2024 and an Artemis 3 human landing mission in 2025. The mission is scheduled to launch no earlier than May, pending the result of a " wet dress rehearsal" countdown. Sanders on Tuesday called for President Joe Biden to issue an executive order to cut off federal contracts to Amazon until the e-commerce company stops what he described as "illegal anti-union activity.Nelson was backdropped during his speech by the agency's Artemis 1 moon rocket, atop the launch pad at NASA's Kennedy Space Center in Florida. Senator Maria Cantwell has led calls for NASA to pick a second lunar lander to stimulate commercial competition and ensure the agency has a backup option in case SpaceX's lander, Starship, falls short. The SpaceX award sparked unsuccessful protests from Bezos' space company. NASA in 2021 picked a lander proposal from SpaceX over Blue Origin's lander proposal to build a spacecraft capable of putting a crew of astronauts on the moon's surface by roughly 2025. "I don't think it's an exaggeration to say this is a national emergency, it is threatening our national security, as well as our economic security,” Raimondo said. The procedural step is needed before the House of Representatives and Senate can begin formal negotiations.Ī Senate Democratic aide said Democrats offered on Wednesday to hold 28 total votes on motions, including 19 from Republicans.Ĭommerce Secretary Gina Raimondo said at a Senate Commerce hearing Wednesday that it was urgent Congress pass funding for semiconductors. Sanders' motion to lawmakers negotiating parts of the bill, which was seen by Reuters, may receive a vote among senators in the coming weeks. The funds for the NASA program would help fund an existing lander contract won by Elon Musk's SpaceX and could potentially go to additional companies other than Blue Origin, such as Northrop Grumman (NOC.N) or Lockheed Martin Corp (LMT.N) - top defense contractors that had partnered on Blue Origin's moon lander proposal in past programs but are now considering lodging their own, individual proposals for the new NASA program. Sanders, long critical of Bezos for what the senator has called "illegal anti-union activity" at Inc (AMZN.O), the technology and commerce giant founded and chaired by Bezos, has criticized the NASA funds as a "$10 billion bailout to Jeff Bezos to fuel his space hobby." A Blue Origin spokesman declined to comment. The bill would authorize $10 billion through 2025 for a lunar lander program that Blue Origin, the space company owned by Bezos, has sought to compete alongside rival companies. The provision is part of a broad bill that would provide $52 billion in semiconductor manufacturing subsidies and authorize additional funds to boost U.S. Senator Bernie Sanders asked lawmakers to delete language from a bill that would fund development of a new lunar lander for NASA, a move seen as part of the senator's effort to nix federal funds that could go to companies owned by billionaire Jeff Bezos.
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While Cobain’s swipes at Rolling Stone and MTV might come across as just bratty posturing, Cobain, from the moment he began playing in bands, was conscious of being part of a new rock generation - and not repeating what he often saw as mistakes and compromises by earlier rock heroes.Ĭobain was so independent that he didn’t play some of his biggest hits, including “Smells Like Teen Spirit,” on the “Unplugged” session. This is a television show.” And sure enough, the songs were re-arranged in the edited version of the performance that was shown on MTV - and the joke about it just being a TV show was omitted. After chatting with band member Krist Novoselic about apparently having a couple of songs in the wrong order, Cobain smiles and tells Novoselic, “Let’s just play them back-to-back. Similarly, he takes delight at one point in the “Unplugged” taping in putting MTV in its place during the December 1993 taping. In a famous Rolling Stone cover photo, his T-shirt carried a wisecrack about Rolling Stone’s ties to the corporate rock culture. But he looked for ways to mock the institutions along the way. The back story: Though Cobain was contemptuous of corporate rock vehicles such as Rolling Stone magazine and MTV, he was practical enough to go along with them because he knew it would help his band sell millions of albums. While Nirvana’s studio albums, “Nevermind” and “In Utero,” remain the essential samples of Cobain’s energy and art, there is an intimacy and gentleness about his performance in “Unplugged” that may be the best glimpse of Cobain the man. I’ll never forget the words of one man in his 40s when I asked him if Cobain meant anything to him: “They ought to pass out shotguns to all the rest of. The rest of the city, however, seemed indifferent, even hostile to Cobain and the young corps of musicians. You can not play videos or modify pictures on HTC unless they are copied to computer, but you can play HTC music directly. With HTC Sync Manager, you can play music and videos from computer, and rotate or crop pictures stored on computer. If you connect your HTC to computer successfully and click “Sync” button on the bottom-left corner, the music, pictures and videos on your HTC will also be displayed on the program(but the files are still on your phone, not on your computer). You can add or remove the locations under each category, such as Music > Music Settings > Display, to change the folders which the program loads data from. When you launch HTC Sync Manager, the program will automatically load local data, like music, pictures and videos, from some system folders on your computer. Display and manage the data from PC and HTC Transfer data from iPhone or Android to HTCġ. For HTC devices that use HTC Sense 3.6 or older, please download HTC Sync. HTC Sync Manager is an upgraded version of HTC Sync. Just as its name implies, HTC Sync Manager can manage data on PC and HTC, and sync data from Android or iPhone to HTC. HTC Sync Manager is an official desktop tool for HTC phones. Unfortunately, the HTC Sync Manager does not yet have this feature.HTC Sync Manager Review About HTC Sync Manager Another concern that many people have regarding this service is the ability to back up the phone’s data. If these data files are not backed up by a third-party service, you could lose them forever. Many people store their pictures, contacts, emails, text messages, and other files on their cell phones. It is important to synchronize your phone’s data so that you do not lose any information along the way. It makes your life much easier when it comes to transferring your phone’s data to another phone or across different devices. This is convenient since this type of synchronization service is fairly new and there are not many applications out there that use this technology yet. You can use it with almost any application that has access to a Windows-based platform. The HTC Sync Manager works great with Windows Mobile or Blackberry devices as well. You do not have to configure settings one at a time like you would with other applications. It is simple to set up and simple to use. You will be prompted by HTC when it is time to install the program onto your phone. There is no software required to use the HTC Sync Manager. If you use more than one cell phone, this feature allows you to use all of them simultaneously. You can synchronize to your PC, your laptop, and your home computer as well. It allows you to change your passwords and more advanced security features. Some of the unique features of the HTC Sync Manager include the ability to synchronize to more than one mobile device. This is convenient and very easy to utilize. If you export data from your phone, you will receive an email with all the necessary information for the import. This makes importing data very easy and ensures that there are no errors when you import. The HTC Sync Manager also allows you to export data to Microsoft Outlook or Google Docs. This is the best way to keep your information private and safe. You will not have access to the phone or any other information except for what you have inputted on the phone. It uses a secure connection to make sure that only you can log into the application. Just select the phone in the list of contacts and you’re all set. The HTC Sync Manager allows for easy synchronization. You can use password protection on the computer and then use a password on the phone to sync. This allows you to use two forms of security. This is perfect if you want to manage multiple phones. It synchronizes your phone list with your computer. This allows you to use the same application on your cell phone as well as the PC. This is one of the best ways to protect data on your HTC Desire phone.Īs a mobile device, the HTC Sync Manager can be used in conjunction with the HTC Desire. In addition, it allows for automatic synchronization across multiple devices with a single login. The HTC Sync Manager is extremely easy to use. It enables users to synchronize their HTC phones to their PCs via a Windows-based PC. One of the most powerful, yet simple and easy-to-use mobile applications today are HTC Sync Manager. 2003) by the function of Activation-Induced (Cytidine) Deaminase (AID) and uracil-DNA glycosylase (Larson and Maizels 2004 Teng and Papavasiliou 2007), thus increases the BCR diversity largely (Li et al. SHM happens at an extremely high rate of about 10 −3 per base pair per division in B cells (Kleinstein et al. Further diversity is introduced by somatic hypermutation (SHM), which introduces mainly single nucleotide substitutions to the rearranged coding genes of antibody. The variety of V, D, and J genes that could be used to recombine provides the basis for the diversity of antibodies, and the random nontemplated nucleotide additions and deletions in the V-D and D-J (V-J for light chain) joining regions also contribute largely to the tremendous diversity of BCR (Nezlin 2001 Rose 1982). During this process, randomly chosen V, (D), and J gene segments are brought into contiguity mediated by the coordinated activities of several enzymes, such as recombination-activating genes (RAG1/RAG2) and terminal deoxynucleotidyl transferase (TdT) (Gauss and Lieber 1996 Schatz and Swanson 2011), and the rearranged variable domain includes four framework regions (FR) and three complementarity-determining regions (CDR) (Fig. During the process of B cell development and maturation, the variable coding genes of BCR undergo a somatic recombination procedure called V(D)J recombination (rearrangement) (Fig. The number of functional genes of each gene family for human and mouse collected by IMGT ( ) is listed in Table 1. For light chains, only V and J gene families are involved in recombination. The immunoglobulin heavy chain variable region is encoded by three gene families, including variable (V), Diversity (D), and Joining (J) genes, which contain numerous gene copies with high sequence homology (Fig. The human IGH, IGL, and IGK genes locate on the chromosomes 14, 22, and 2, respectively. The variable region diversity of BCR determines the diversity and specificity of antigen recognition. Antibody is a Y-shaped protein composed of two identical large heavy chains (encoded by the gene IGH) and two identical small light chains (λ or κ) (encoded by the gene IGL or IGK) (Fig. Antibodies are encoded by a very unique protein-coding system, in which somatic rearrangements happen in the coding genes. Generation of antibody diversityĪntibody, also known as immunoglobulin (Ig), is the molecule produced by B cell that can specifically recognize and neutralize a variety of antigens. The precursor of T cells migrate through peripheral blood to the thymus, where they finish the differentiation and the maturation, while the maturation of B cells from the progenitors occurs mostly in the bone marrow. Both T and B cells originate from the pluripotent stem cells in the bone marrow. Bearing the significant functions in the immune system, T and B lymphocytes are derived, differentiated, and mature in different organs and tissues. Therefore, the diversity of TCR and antibody repertoire could reflect the adaptive immune status to some extent. In addition, pressures from both the internal and the outside environment, such as pathogen exposure, tumor formation, and autoimmune reaction, could affect the diversity of TCR and antibody by expanding the “pressure”-associated T/B cells. A powerful adaptive immune system relies on the generation of diversified TCRs and antibodies to recognize the enormous variety of antigens. T and B lymphocytes are two prolific and functionally important cells that play pivotal roles. The adaptive immunity consists of two major components, cellular immunity and humoral immunity, which are highly specific to particular pathogens. However, challenges still remain both in the experimental pipeline and the analytical tools to handle the huge amount of data, and various potential solutions are being developed to fulfill the comprehensive application and translation of this technique. The emergence of high-throughput sequencing (HTS) technique enables scientists to investigate the repertoire in an unprecedented level. Historically, scientific reports on the TCR and BCR repertoire are unlikely to grasp the whole picture due to the unavailability of high-throughput and sensitive tools. On the other hand, antibodies can bind to and neutralize the antigens directly. The diversified TCRs can recognize and bind to the various epitopes of the antigens presented by the major histocompatibility complex (MHC) molecule of the antigen presenting cells and form a TCR-antigen-MHC structure complex. The normal function of adaptive immunity relies on the generation of diverse T cell receptors (TCRs) that are expressed on the cell membrane of T lymphocytes, and B cell receptors (BCRs), also known as immunoglobulin (Ig) or antibody in the secreting form, which are expressed by B lymphocytes. Nintendo Switch, Macintosh added by Kam1Kaz3NL77. Image: Super Rare Games Inmost, from developer Hidden Layer Games, is an intriguing title that tells a dark and at times troubling tale. Know about this game? Add your expertise to help preserve this entry in video game history! Console Generation Exclusives: Nintendo Switch.Source: Steam Store Description Spellings Explore every inch of the world to find secret passages.Scale the environment by sneaking past enemies, luring them into deadly traps, solving puzzles and slicing down foes Inmost is a Puzzle-Platformer released on mobile devices in 2019 and ported to PC and Nintendo Switch in 2020. One interweaving story, set across two worlds 0:00 / 1:50 INMOST - Launch Trailer - Nintendo Switch Nintendo of America 9.01M subscribers Subscribe 7.It was clear, how the main theme of Inmost is dark and depressive. Three main characters, each with their own unique gameplay styles They took a huge gamble for creating Inmost, risking the whole studio, but thankfully it paid off, because when Inmost was released on Steam and Switch it was praised by critics and gamers.A ghoulishly atmospheric, yet beautiful pixel art world.In an old abandoned castle, you’ll need to explore every nook and cranny, avoid detection, slice through enemies and spring deadly traps in order to escape the evil that lurks within… One interconnecting tale of suffering, sacrifice, and the family in the middle of it all. The land tells the story a dark fairytale grief and strife and hurt and loneliness. INMOST is an atmospheric, story-driven puzzle platformer, following three playable characters within one dark, interconnecting story.Ī Knight sworn to the forces of darkness. Inmost for Switch game reviews & Metacritic score: Inmost is an atmospheric, story-driven puzzle platformer, following three playable characters within one dark, interconnecting story. The highlight of this game is the atmosphere. POSTCARD FROM ITALY: Panettone: Sweet treat from inside prison (Video) Panettone, a sweet Italian bread that's a tradition come holiday time. American Museum of Natural History, New York City.Most Christmas trees are cut, but one very special tree is folded! The American Museum of Natural History in New York City features a tree decorated top to bottom with origami insects, to celebrate the opening of the museum's new insectarium early next year. Album: "A Family Christmas" by Andrea Bocelli, Matteo Bocelli and Virginia BocelliĬHRISTMAS TREES: The origami holiday tree (Video).This year they are joined by the great Andrea Bocelli and his children, Matteo and Virginia, who sing "The Greatest Gift." Recorded inside the Oculus at New York's World Trade Center. It's become a "Sunday Morning" holiday tradition: A performance by the Young People's Chorus of New York City. 'TIS THE SEASON: Andrea Bocelli and family perform "The Greatest Gift" (Video) Andrea, Matteo and Virginia Bocelli with the Young People's Chorus of New York City. "Sunday Morning" remembers some of the notable figures who left us this week, including Pittsburgh Steelers great Franco Harris. "Sunday Morning" correspondent Conor Knighton harks back to his childhood, and the ghosts of Christmases past, with the magic of the holidays preserved in home movies that captured Christmas presents, carols, and family traditions, still shining beneath the static and snow of old videocassettes. "Amazing Grace: The Story of America's Most Beloved Song" by Steve Turner (Ecco), in Trade Paperback and eBook formats, available via Amazon, Barnes & Noble and IndieboundĬonor Knighton and his siblings on Christmas Morning 1988, recorded for posterity via VHS tape. Half a century later his words were paired with music, and would become one of the best-known hymns in the world, "Amazing Grace." Correspondent Ramy Inocencio talks with music journalist Steve Turner about the song's history, and with folk singer Judy Collins, whose 1970 performance marked a rebirth of the beloved spiritual. John Newton, a slave trader-turned-abolitionist, gave a sermon about personal redemption. On January 1, 1773, in Olney, England, The Rev. MUSIC: The story of "Amazing Grace" | Watch Video Solving a Rubik's Cube takes a certain talent an entirely different talent is employed by 16-year-old Daniella Chaim, who uses Rubik's Cubes as her artistic medium. Daniella Chaim, The Cubist, "paints" with Rubik's Cubes.ĪRTS: The Cubist - Turning Rubik's Cubes into art (Video) Jeri Wakefield, of Dallas, takes the holiday to new heights with a Christmas tree house, turning a 100-year-old pecan tree in her backyard into a yuletide wonderland. Kindred Thoughts Bookstore, Bridgeport, Conn.ĬHRISTMAS TREES: How about a Christmas tree house? (Video).National Oceanic and Atmospheric Administration (NOAA).This game.COVER STORY: Good news you missed in 2022 | Watch VideoĪ lot of stuff happened this past year, not all of it bad! Correspondent David Pogue brings you some of the headlines from 2022 that will gladden your heart, from scientific advances, to the boom in independent bookstores, and long-delayed justice for unheralded musical artists. : Saboteur! Saboteur! I'm going to kill you for real.the game is over, I'm really going to shoot you! Andy Saboteur! Saboteur! I'm going to kill you for real. What are we doing? What's the game? I want in. Karen: Oh, the vending machines! How did we miss that? We're just trying to get these chips for Karen.Īndy: Did you.
Whether they play professionally, for fun, or are just a sideline watcher, the soccer fan in your life deserves a unique gift this holiday season. With the potential farewell of two of the greatest player’s all time and the rise of the next generation on the world’s biggest stage, the tournament promises to be one to remember.Īs one of the world's biggest sporting events and the holidays happen simultaneously, it's the perfect time to score points with the diehards or players in your life by giving them something that really speaks to their passion for their favorite sport. Any order that is not picked up after 30 days will be returned to stock, and you will be issued a store credit.After years of tumultuous preparations, the 2022 FIFA World Cup is finally underway, which means all your favorite soccer devotees will be busy watching match after match screaming GOAAAAAAL at their TVs.
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